Developing a functional urinary bladder: A neuronal context

JR Keast; CJA Smith-Anttila; PB Osborne

Journal article

Developing a functional urinary bladder: A neuronal context

JR Keast, CJA Smith-Anttila, PB Osborne

Frontiers in Cell and Developmental Biology | FRONTIERS MEDIA SA | Published : 2015

DOI: 10.3389/fcell.2015.00053

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Abstract

The development of organs occurs in parallel with the formation of their nerve supply. The innervation of pelvic organs (lower urinary tract, hindgut, and sexual organs) is complex and we know remarkably little about the mechanisms that form these neural pathways. The goal of this short review is to use the urinary bladder as an example to stimulate interest in this question. The bladder requires a healthy mature nervous system to store urine and release it at behaviorally appropriate times. Understanding the mechanisms underlying the construction of these neural circuits is not only relevant to defining the basis of developmental problems but may also suggest strategies to restore connectiv..

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University of Melbourne Researchers

Janet Keast Author

Peregrine Osborne Author

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Awarded by National Science Foundation

Funding Acknowledgements

This work was supported by the National Institutes of Health (5U01 DK094479 to JK) and the National Health and Medical Research Council of Australia (1003512 to PO and JK, 1022941 to JK).